Current State of Pharmacodynamic Target Attainment in Critically Ill Patients with Severe Sepsis in Canadian Icus: Prospective Cohort Study-Juniper Publishers
Juniper Publishers - Journal of Anesthesia Abstract Objectives: We sought to determine the rate of pharmacodynamic target attainment of antibiotic therapy for critically ill patients with severe sepsis in Canadian ICUs. Methods: In this multicenter observational study, adult Canadian ICU patients with severe sepsis were prospectively followed. The minimum inhibitory concentration (MIC) of the organism was obtained from hospital’s microbiology laboratory, and pharmacodynamic targets (PD) of the prescribed empiric antibiotics were calculated using population pharmacokinetic parameters to estimate the rate of PD target attainment. The primary outcome was the proportion of patients who attained PD target. We performed sensitivity analysis varying the elimination rate constant (ke), volume of distribution (Vd), and MIC parameters. Results: Sixty-nine pairs of antibiotic and MIC were evaluated in 43 patients. In the base case, PDtarget attainment was achieved in ...