Thoracic Epidural Analgesia Lessens Inflammatory Response to Coronary Artery Bypass Grafting Surgery -Juniper Publishers
Juniper Publishers - Journal of Anesthesia Abstract Objectives: To evaluate the effects of preoperative thoracic epidural analgesia (TEA) on inflammatory response of patients undergoing on- pump coronary artery bypass graft (CABG) surgery under general anesthesia (GA). Patients & Methods: Eighty-eight patients were divided into two groups; Group TEA received TEA and GA and Group GA received GA alone. Blood samples were collected preoperatively (T 0 ), 4-hr (TJ, and one (T 2 ) and two (T 3 ) days after surgery for ELISA estimation of serum interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor (TNF)-α. Intraoperative (IO) and postoperative (PO) data were collected. Results: Patients of group E had significantly lower IO hemodynamic measures, shorter time for hemostasis and wound closure and less IO blood loss than patients of group G. Amount of 1st PO day wound drainage was significantly less, and durations of mechanical ventilation (MV), ICU stay and ...