Current State of Pharmacodynamic Target Attainment in Critically Ill Patients with Severe Sepsis in Canadian Icus: Prospective Cohort Study


Authored by Clarence Chant

In this multicenter observational study, adult Canadian ICU patients with severe sepsis were prospectively followed. The minimum inhibitory concentration (MIC) of the organism was obtained from hospital’s microbiology laboratory, and pharmacodynamic targets (PD) of the prescribed empiric antibiotics were calculated using population pharmacokinetic parameters to estimate the rate of PD target attainment.

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