Current State of Pharmacodynamic Target Attainment in Critically Ill Patients with Severe Sepsis in Canadian Icus: Prospective Cohort Study
Authored by Clarence Chant
In this multicenter observational study, adult Canadian
 ICU patients with severe sepsis were prospectively followed. The 
minimum inhibitory concentration (MIC) of the organism was obtained from
 hospital’s microbiology laboratory, and pharmacodynamic targets (PD) 
of the prescribed empiric antibiotics were calculated using population 
pharmacokinetic parameters to estimate the rate of PD target attainment.
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