Idiopathic Hyperammonemia after Orthotopic Lung Transplantation- Juniper Publishers- Journal of Anesthesia & Intensive Care Medicine
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Idiopathic Hyperammonemia after Orthotopic Lung Transplantation
Authored by Tyson Kathleen
Idiopathic hyperammonemia is characterized by increased serum ammonia
levels (>200umol/L) and is sometimes associated with normal to
slightly elevated liver function tests [1]. These patients often present
with encephalopathy, cerebral edema, seizures, and coma. Idiopathic
hyperammonemia has been reported after high dose chemotherapy, and organ
transplants including Orthotopic lung transplant [2]. Hyperammonemia is
a rare, severe, and often fatal complication. There are few cases
reported in the literature since 1997, including one retrospective
analysis of 807 lung transplants; only 8 patients were diagnosed with
hyperammonemia [3]. The exact mechanism of idiopathic hyperammonemiais
not fully understood with congenital or acquired defects in ammonia
metabolism, as well as bacterial infection having been described [3].
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