Kappa Receptors Agonist in Postoperative Pain-Juniper Publishers
Juniper Publishers-Journal of Anesthesia
Abstract
The peripherally acting kappa receptors agonist CR845
(difelikefalin) is currently in late development by Cara Therapeutics,
for the treatment ofuremic pruritus, post-operative pain and pain in
osteoarthritis. The principle of treating pain via a peripheral acting
opioid, is supposed to have special advantages, among which the absence
of central opioid side effects, and has actually been defined already in
the last century. Phase I development of CR845 started in 2008, phase
II studies have been completed, and phase III is ongoing for two
formulations: an intravenous formulation for postoperative analgesia and
uremic pruritus, and an oral formulation for treatment of chronic pain
in osteoarthritis. However, as primary scientific data on CR845 in peer
reviewed journals to date are absent, we can only evaluate the documents
produced by the company, among which press releases of CARA
Therapeutics, presenting results of a number of preclinical and clinical
studies. We present a profile of CR845 based on this information,
especially since CR845 is first in class and the principle seems to
holds promises for the treatment of pain and itch.
Introduction
Peripheral kappa receptor agonists for pain
There is an ongoing intense debate about pros and
cons of prescription of opioids, and it is clear that less or
non-addictive opioids would be greatly welcomed. Peripherally acting
opioid agonists may be such analgesics. The potential advantages of
kappa receptor agonists restricted to the peripheral nervous system are
outlined already [1].
There are a number of such compounds in development,
such as asimadoline (EMD-61753), D-Arg2, Lys4-Dermorphin-(1-4)- amide
(DALDA), enadoline, TRK-820, U50488, ICI-204,448and FE200665 and
families of compounds based on certain scaffolds in the laboratory, such
as tetrahydroisoquinoline quaternary derivatives. TRK-820 is a
peripheral kappa receptor agonist from Toray Industries, Inc., also
known as nalfurafine, and is available in Japan and registered since
2009 for the treatment of uremic pruritus, one of the current
development indications for CR845 [2].
Naloxegol is available since 2014 in the USA as a once-daily oral
therapy indicated for the treatment of opioid- induced constipation.
CR845 originating from the Swiss company Ferring
Pharmaceuticals and the compound is also known as CKD- 943, FE 202845
and MR13A9. A prototype of this drug was well tolerated in humans, with
no reports of dysphoria or hallucinations, and as effective as oxycodone
in a human model of acute visceral pain [3].
However, the preclinical profile was suboptimal due to low orally bio
available. CR845 was positioned as a second-generation peptide, orally
bio available, and CARA reported to have completed Phase I clinical
trials in 2009 [4].
The intravenous formulation is in phase III development for
postoperative pain and uremic pruritus. The oral formulation for the
treatment of chronic pain in phase II.
Publications on CR845 in peer reviewed articles
In addition to company press releases we could find only3published posters on the compound [5-7].
In addition we identified two book chapters (the same chapters, written
by the same authors), published in 2015, without giving additional
details [8,9].
The first poster presented data from an un blinded, pooled
treatment-emergent adverse events analysis, based on in a total of 368
patients, from 3 double-blind, randomized, placebo-controlled, Phase 2
clinical studies. The second poster presented the preclinical profile of
the drug, and the last poster, presented the results of a phase II
bunionectomy study.
Preclinical profile
The preclinical profile is described in a company
poster: 'Preclinical Profile of CR845: A Novel, Long-Acting Peripheral
Kappa Opioid Receptor Agonist', presented at the IASP in 2008 [10].
CR845 is presented as highly selective kappa agonist, without
off-target. In various pain paradigms CR845 dose dependently inhibited
pain behavior. In the acetic acid induced writhing in male mice 0,01,
0,03, 0,1 and 0,3mg/kg IV were tested versus vehicle and ED50 was
0.07mg/kg IV. In an abdominal pain model ED50 was 0.3mg/kg IP or IV. In a
pain-inflammation model 0.3 and 1mg/kg were significantly better than
vehicle. In a neuropathic pain model ED50 was 0.38mg/kg IV. In an itch
model, 48/80 or 5'GNTI induced pruritus, CR845 0,1 and 0,3mg/ kg
significantly inhibited scratch behavior, ED50 = 0.08mg/kg IV.
Early studies
All the data are based on press releases on the CARA
company website. Apr 28, 2008 CARA announced the initiation of its I.V.
phase I program, and defined the compound as: "long-acting peripheral
kappa opioid receptor agonist". On August 5, 2008, the results of a
phase I study, evaluating the IV formulation, was presented at the
company's website [11].
In a double-blind, randomized, placebo-controlled, single escalating
intravenous dose study was evaluated in 54 healthy male and female
volunteers, and the results showed linear, dose-proportional increases
in systemic exposure to CR845. CR845 infusion also was said to trigger
surrogate markers for peripheral kappa opioid receptor activation. Phase
I data of the oral formulation were communicated on April 3, 2012, and a
robust bioavailability and pharmacologic activity was reported for the
oral formulation [12].
On February 8, 2010, the company announced further positive phase II
data for in postoperative pain, and significant pain relief was observed
in CR845-treated patients over placebo, more details were given in 2012
[13].
Further phase II study
In 2013 the company presented the results of a phase II study in the treatment of pain following bunionectomy [14].
In the complete analysis an I.V. 0.005mg CR845/kg/dose CR845, resulted
in significantly greater pain reduction than placebo In 2015 CARA
presented results from a double-blind, randomized, placebo-controlled
trial in 65 dialysis patients, active drug reduced itch significantly
compared to those receiving placebo. In the same year Cara announces
positive results osteoarthritic pain knee or hip, based on a multiple
ascending dose trial in 80 patients: 0.25mg, 0.5mg, 1.0 mg and 5.0mg,
dosed twice a day during a two-week period. Half of all patients in the
5.0mg dose group reported at least a 30 percent reduction in their pain
score at the end of the treatment period).The company also reported
dose-proportional PK effects in the 1 and 5mg range.
Conclusion
The new peripheral acting kappa opiate agonist CR845
has been evaluated within the company CARA for a period of 9 years since
first start of development in 2008. The data communicated therefore has
to be interpreted given the conflict of interest of the company and her
representatives. Based on the company information reviewed however, the
profile of the drug seems quite interesting: CR845 is a small peptide
molecule, without penetration in the central nervous system, effective
against acute, post-surgical pain and in osteoe arthrosis pain, with
some side effects, such as facial tingling or numbness, dizziness and
fatigue. Human abuse liability (HAL) study does not raise red flags, and
there seems to be no negative effects of respiratory depression. This
is in line with separate analysis of this group of compounds [15].
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